Congestive Heart Failure: Causes of Sudden Worsening

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01081925

Enrollment

100

Registered

2010-03-05

Start date

2010-02-28

Completion date

2012-02-29

Last updated

2010-03-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Congestive Heart Failure

Keywords

Congestive Heart Failure, Cardiac Failure

Brief summary

The purpose of the study is to recognize main causes of acute decompensation of chronic congestive heart failure.

Detailed description

Congestive heart failure (CHF) presents a very significant cause of morbidity and mortality. The prevalence of CHF is between 2 and 4% and rises with age (in 70- to 80-year-old people is between 10 and 20%). CHF is the cause of 5% of all acute hospital admissions and accounts for 2% of expenses on health. The most common causes of worsening of the chronic CHF are ischemia, arrhythmias, valvular dysfunction, systemic or pulmonary hypertension, volume overload or fluid retention, high output conditions (infection, anemia, thyrotoxicosis), drugs (NSAIDs, cyclo-oxygenase (COX) inhibitors, thiazolidinediones) and medication nonadherence. The goal of this study is to determine the proportion of various reasons of acute worsening of CHF, using commonly available methods including assessment of serum drug levels.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* able to provide informed consent * aged 19 years or more * history of heart failure of at least one month * examined or hospitalized for acute dyspnea at rest or with minimal exertion * clinical signs of fluid overload defined as at least one of following: * rales * jugular venous distension * peripheral edema * pulmonary congestion on X-ray * NT-proBNP above 210 pmo/l

Exclusion criteria

* none

Countries

Czechia

Contacts

Primary ContactRadek Pelouch, MD

pelouch@centrum.cz00420495834740

Backup ContactJiri Ceral, MD

ceral@seznam.cz00420495832652

Outcome results