Parkinson's Disease
Conditions
Keywords
Parkinson's disease, deep brain stimulation, GI motility
Brief summary
Parkinson's disease is characterized by extra-pyramidal symptoms as well as digestive involvement with gastrointestinal motility (GI) impairment. Deep brain stimulation has been recently developed as a successful treatment for extrapyramidal symptoms. In addition, preliminary reports suggest that this therapy might be successful to relieve GI symptoms as well. The aim of this study is therefore to assess the effect of deep brain stimulation on GI voluntary as well as involuntary motility.
Interventions
DEVICEDeep brain stimulation
Comparison ON vs OFF
Sponsors
University Hospital, Rouen
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patient over 18 yo * patient with Parkinson's disease implanted for deep brain stimulation * patient responders to deep brain stimulation (UPDRS improved by at least 40%) * patient covered by the french health care system * patient not taking anti-parkinsonian medication the day before evaluation * French speaking
Exclusion criteria
* patient below 18 yo * pregnancy * Severe psychiatric or cognitive disorders * diabetes mellitus * morbid obesity * compulsive eating disorders * diffuse GI motility impairment (except Parkinson's disease) * other evolutive neurologic disorders * previous history of significant GI resection * inability to swallow or defecate when asked
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anal pressure | 2 hours |
Countries
France
Outcome results
None listed