Evaluation of Optical Coherence Tomography.

Evaluation of the Sensitivity and Specificity of Optical Coherence Tomography Combined With Fundus Color Photos for Diagnosis of Choroidal Neovessels in Age-related Macular Degeneration

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01080898

Acronym

ESSO

Enrollment

151

Registered

2010-03-04

Start date

2010-04-30

Completion date

2010-10-31

Last updated

2012-07-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Age-Related Macular Degeneration, Choroidal Vessels; Anastomosis

Keywords

Age - Related Macular Degeneration, Optical Coherence Tomography, Choroidal neovascularization, FLORESCEIN Angiography, Fundus photographs

Brief summary

Determination of the sensitivity and specificity of different combinations of imaging techniques (spectral domain optical coherence tomography, fundus photography and fluorescein angiography) used for the diagnosis of choroidal neovessels complicating age -related macular degeneration. This information will help to determine the choice of the most suitable combination for the above diagnosis.

Detailed description

The following combinations will be studied: spectral domain optical coherence tomography (OCT) + fundus photography; fluorescein angiography + fundus photography and the combination of all three techniques (OCT+ fundus photography + fluorescein angiography).The sensitivity and specificity of the latter combination will be assessed by comparison with the results for this combination reported by several readers. Inter- and intra-observer reproducibility of the different combinations will also be studied.

Interventions

OTHERtests

color photographs, FLUORESCEIN angiography and OCT

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age\> 50 years * First visit for suspicion of choroidal neo-vessels complicating age related macular degeneration * Fundus color photographs , FLUORESCEIN angiography and OCT prescription

Exclusion criteria

* Age \< 50 years * Diabetes * Central vein occlusion Macular hole Epi-retinal membrane Retinal detachment Macular hemorrhage more than the 1/3 of the lesion * History of macular laser, PDT or intra-vitreal injection

Design outcomes

Primary

Measure	Time frame
Evaluation of the sensitivity and specificity of optical coherence tomography combined with fundus color photos in the diagnosis of choroidal neovessels in age- related macular degeneration.	all outcome the day of inclusion

Secondary

Measure	Time frame
Evaluation of the sensitivity and specificity of optical coherence tomography combined with fundus color photography, and of fluorescein angiography combined with fundus color photography.	all outcome the day of inclusion
Rate of unusable images for each technique	all outcome the day of inclusion
Evaluation of the sensitivity and specificity of fluorescein angiography combined with fundus color photography in the diagnosis of choroidal neovessels in age - related macular degeneration.	all the outcome the day of inclusion
Evaluation of the sensitivity and specificity of fluorescein angiography combined with fundus color photography for the diagnosis of sub-categories of choroidal neovessels.	all outcome the day of inclusion
Evaluation of the intra-and inter-reader reproducibility of the diagnosis of choroidal neovessels in age-related macular degeneration using fluorescein angiography combined with fundus color photography.	all outcome the day of inclusion
Evaluation of the sensitivity and specificity of optical coherence tomography combined with fundus color photography for the diagnosis of sub-categories of choroidal neovessels	all outcome the day of inclusion

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026