Wrinkles
Conditions
Keywords
Platelet rich plasma, PRP, wrinkles, MyCells®, CREATE, Life Source Medical Centre, Dr Tan Kok leong
Brief summary
Wrinkles result from imperfect repair of the dermal layer resulting in loss of collagen commonly due to ageing, smoking and sun exposure. Platelet rich plasma (PRP) contains a host of growth factors, which have been used in other clinical trials for various medical conditions such as tendonitis, and also in surgery such as the surgical repair of facial defects. Results from these clinical trials suggest that PRP helps in collagen formation and organisation to promote healing of tissues. This study attempts to document the clinical effects of intradermal injection of PRP on wrinkles.
Detailed description
10 selected participants will have 10 ml of blood removed for platelet extraction with MyCells®. The resulting Platelet rich plasma will be injected intradermally into the facial wrinkles.
Interventions
DEVICEMyCells® (injection of platelet rich plasma)
PRP contains at least 1,000,000 platelets per mm3 or 2-6 times the native concentration of whole blood at a pH of 6.5 to 6.7
Sponsors
Novena Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Adults more than 21 years of age * Dis-satisfied or anxious about facial wrinkles (total wrinkle length more than 1cm)
Exclusion criteria
* Pregnant women. * Psychiatric patients. * Known bleeding disorders such as platelet dysfunction syndrome, thrombocytopenia, hypofibrinogenemia * Anticoagulants(eg.aspirin, warfarin) * Had other wrinkle therapy for less than a month.(laser, peels, injections) * Had facelift surgery for less than a year. * Diseased states such as organ failure, severe anaemia, cancer, acute/chronic infections. * Involved in personal litigation against an aesthetic service provider
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total Wrinkle Length | 3 months | All visible wrinkles are measured and the length is summed up to give the Total Wrinkle Length. Comparison of pre treatment and post treatment Total Wrinkle Length will be studied. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Side effect / Adverse Event | 3 months | Side Effects / Adverse Events to be monitored include allergic reaction, nerve injury and cavernous sinus thrombosis. |
Countries
Singapore
Outcome results
None listed