Keloids, Hypertrophic Scars
Conditions
Keywords
Hypertrophic scars, Topical silicone gel, Scar thickness, Scar Color, Scar pliability, Scar appearance
Brief summary
Keloids and hypertrophic scars are a common subject of dermatologic consultations. Therapeutic management of such conditions remains challenging because of their high rate of recurrence and lack of curative treatment.
Detailed description
Silicone gel Sheeting (SGS) is one treatment modality that has proven effective for treatment of hypertrophic scar. One disadvantage of SGS is its application technique. To be effective, SGS must be applied on the scar for at least 12 hours daily. Topical silicone gel is a novel therapy that has shown promising result on scar prevention. However, the efficacy and safety of topical silicone gel for treatment of hypertrophic scar has not been confirmed.
Interventions
OTHERTopical silicone gel
Topical silicone gel will be applied to the scar twice daily for a period of 8 weeks
OTHERVaseline
Topical petrolatum gel will be applied to the scar twice daily for a period of 8 weeks
Sponsors
Mahidol University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* subjects at least 18 years old * subjects with hypertrophic abdominal scar * Have not received treatment on the scar at least 1 month prior to the enrollment.
Exclusion criteria
* subject who has previous history of silicone allergy * subject who smoke cigarette * subject who was treated with x-rays irradiation in the past
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scar thickness | 1, 2 and 5 months after initiation of treatment |
Secondary
| Measure | Time frame |
|---|---|
| Clinical assessment on overall scar appearance | 1, 2 and 5 months after initiation of treatment |
Countries
Thailand
Outcome results
None listed