Lymph Metastases, Oropharynx Metastases, Squamous Cell Carcinoma of the Oral Cavity
Conditions
Keywords
oropharynx and lymph node metastases from an unknown primary tumor
Brief summary
In this study, the feasibility of optical imaging and FDG-PET in the evaluation of radiation-induced mucositis will be evaluated.
Interventions
PROCEDUREendoscopic examination
on a weekly basis during 7 weeks
PROCEDUREFDG-PET
once pre-radiotherapy and once 2 weeks after initiation of radiotherapy
Sponsors
University Hospital, Ghent
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Non-operated histologically confirmed squamous cell carcinoma of the oral cavity, oropharynx (except the posterior wall) and lymph node metastases from the unknown primary tumor (CUP) * Stage T1-4; Tx N+ for the CUP * Multidisciplinary Group of Head and Neck Tumors at Ghent University Hospital decision of radical radiotherapy (±concurrent chemotherapy) * Informed consent obtained, signed and dated before specific protocol procedures.
Exclusion criteria
* Age \< 18 years * Pregnant or lactating women * Active infection or fistula in the oral/oropharyngeal mucosa * Previous cancer of the oral cavity and the oropharynx * Prior head-and-neck radiotherapy * Expectation of non-compliance with the study protocol * Known allergy for topical anesthetics (Xylocaïne)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Feasibility of optical imaging in the evaluation of radiation-induced mucositis. | weekly assessment during 7 weeks |
| Feasibility of FDG-PET in the evaluation of radiation-induced mucositis. | 2 weeks after radiotherapy |
Countries
Belgium
Outcome results
None listed