Local Anesthetic Continuous Preperitoneal Infiltration and Wound Hyperalgesia

Effect of Local Anesthetic Continuous Preperitoneal Wound Infiltration on Incisional Hyperalgesia Following Colorectal Laparoscopic Surgery

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01077752

Acronym

CATCH

Enrollment

Registered

2010-03-01

Start date

2010-02-28

Completion date

2013-02-28

Last updated

2014-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain, Postoperative

Keywords

Pain, postoperative, Local infiltration, Hyperalgesia, postoperative, Local anesthetic, ropivacaine, lidocaine, Colorectal laparoscopic surgery, Pain management after colorectal laparoscopic surgery

Brief summary

In this multicenter, randomised, placebo-controlled, double-blind trial, hyperalgesia area around the scarce following colorectal laparoscopic surgery (piece removal) will be assessed in 3 groups of patients : group 1: continuous ropivacaine preperitoneal infusion, group 2 : intravenous lidocaine infusion, or group 3 : control group without local anesthetics. All patients will receive parenteral analgesia combining acetaminophen and morphine.

Detailed description

Besides hyperalgesia assessment, immediate postoperative and long-term pain, morphine consumption, and endocrin-metabolic response will be evaluated in this study.

Interventions

DRUGcontinuous ropivacaine preperitoneal infusion

Bolus of 20 mg after the surgery then 20 mg per hour during 48 hours

DRUGintravenous lidocaine infusion

Bolus of 60 mg after the surgery then 60 mg per hour during 48 hours

DRUGparenteral analgesia combining acetaminophen and morphine

parenteral analgesia combining acetaminophen and morphine

DRUGNaCl

NaCl

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Age 18 to 80 * ASA status 1 - 3 * Colorectal laparoscopic surgery with piece removal * French speaking * Written informed consent

Exclusion criteria

* laparoscopy without colorectal extraction * chronic pain * analgesic consumption during the 24 hours previous to the surgery * morphine and LA intolerance * drug addiction * inflammatory bowel disease * general inflammatory disease * sepsis * anemia \< 10 gr/dl * liver or renal or cardiac insufficiency * uncontrolled diabetes * preoperative consumption of opiate/corticosteroid/beta-blockers, and anti-arrhythmic drugs, MAOIs, neuroleptics. * preoperative consumption of NSAIDs excluding aspirin referred cardiology

Design outcomes

Primary

Measure	Time frame
Pericicatricial hyperalgesia area	72 hours after surgery

Secondary

Measure	Time frame
Pain intensity (rest/mobilization and long-term)	72 hours, 3 months and 6 months after surgery
Morphine consumption	During 5 days after surgery

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026