Comparison of Two Electroencephalogram (EEG)-Derived Indices With Electroencephalogram Signals

Comparison of Bispectral Index and Entropy With Electroencephalogram During Sevoflurane Anaesthesia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01077674

Enrollment

Registered

2010-03-01

Start date

2009-12-31

Completion date

2011-03-31

Last updated

2013-10-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anaesthesia, Surgery

Keywords

Electroencephalogram, Entropy, BIS, Sevoflurane

Brief summary

Bispectral Index (BIS) and Entropy indices will be compared with each other, and to raw EEG signals in patients receiving sevoflurane anaesthesia. BIS and Entropy numbers often differ significantly from each other during surgery, and the reason for this has not been studied in detail, therefore remaining only poorly understood. BIS and Entropy, together with multi-channel EEG, will be collected and analyzed later on. Course of anaesthesia and surgery will be annotated. All relevant information from anaesthesia monitor will be collected on computer.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

Inclusion criteria

* Planned surgery necessitating general anaesthesia * Expected duration of anaesthesia 30 min or more * Need of endotracheal intubation * ASA status 1, 2 or 3

Exclusion criteria

* Significant disorders of the autonomic or central nervous system * Family history of malignant hyperthermia * Clinical history of anaphylactic reaction against inhaled anaesthetics * Disability to communicate with Finnish language

Design outcomes

Primary

Measure	Time frame
Morphology of electroencephalogram during discrepancy between Entropy and BIS index values	15 minutes

Countries

Finland

Outcome results