Chronic Calculous Cholecystitis
Conditions
Keywords
Cholecystectomy, Cholecystitis, Laparoscopy, Cholelithiasis, Operative trauma
Brief summary
The aim of this work is to evaluate which of the two types of operation (traditional/open and laparoscopic) has more impact on patients who were operated electively due to their chronic calculous cholecystitis.
Detailed description
The prospective, single center, randomized study includes 120 patients who are operated electively - 60 patients operated laparoscopically and 60 patients operated traditionally. Biohumoral and endocrine parameters of response to trauma are determined from 24 hour urine and blood: adrenalin, noradrenalin, metabolites of corticosteroid hormone - 17- hydroxyl and 17- keto steroid (HPLC method), C reactive protein and albumin, glycemia, creatine phosphokinase, lactate dehydrogenase, sedimentation of erythrocytes and serum concentration of potassium.
Interventions
PROCEDURELaparoscopic cholecystectomy
PROCEDUREOpen Surgery
Sponsors
Medical School of Podgorica, Montenegro
General Hospital Berane, Montenegro
Ministry of Health, Montenegro
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Chronic Calculous Cholecystitis
Exclusion criteria
* Previous Biliary Surgery * Cholangitis * Obstructive jaundice
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To determine biohumoral and endocrine parameters of response to trauma | first 24h after the surgical intervention | Urine and blood biochemical analyses: adrenalin, noradrenalin, metabolites of corticosteroid hormone - 17- hydroxyl and 17- keto steroid (HPLC method), C reactive protein and albumin, glycemia, creatine phosphokinase, lactate dehydrogenase, sedimentation of erythrocytes and serum concentration of potassium |
Countries
Montenegro
Outcome results
None listed