Borderline Personality Disorder
Conditions
Keywords
Borderline Personality Disorder, Transcranial Magnetic Stimulation, Neuropsychological Test, Randomised Control Trial
Brief summary
Primary purpose : to assess the effect on neuropsychological tasks related to planning of 10 daily sessions of right dorsolateral prefrontal cortex with High-frequency repetitive transcranial magnetic stimulation (rTMS) on borderline personality disorder (BPD) patients. Hypothesis : BPD patients receiving 10 sessions of rTMS will have greater improvement in the average number of move to achieve tasks of the Tower of London, than those receiving sham rTMS.
Interventions
PROCEDURErepetitive Transcranial Stimulation Magnetic (rTMS)
The motor threshold was determined in each subject once, before treatment. This was defined as the lowest stimulation intensity capable of inducing a visible movement at least five times out of 10 stimulations. The position of the right dorsolateral prefrontal cortex was defined as 5 cm anterior (in a parasagittal line) to the motor cortex. The stimulus intensity was 80% of the patient's motor threshold intensity. Treatments were given for 20 minutes per day over 10 working days.
PROCEDUREsham rTMS
sham rTMS
Sponsors
University Hospital, Toulouse
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* 20 to 45 years old * Borderline Personality Disorder (Diagnostic Interview for Borderline Personality Disorder \> 8) * psychiatric follow-up * righthander * informed consent * affiliated to medical insurance
Exclusion criteria
* bipolar disorder * substance use disorder * Major Depressive Disorder or Stress Post Traumatic Disorder * history of epilepsy * neurosurgery * cardiac pacemaker * lefthander * involuntary admission * participation in an other research * legal guardianship * poor mastery of french.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tower of London | Inclusion, 15th day, 30th day and 3rd month |
Secondary
| Measure | Time frame |
|---|---|
| Micro-World Test | Inclusion, 15th day and 3rd month |
| Borderline Personality Disorder Severity Index | Pre-inclusion, 30th day and 3rd month |
| Balloon Analog Risk Task | Inclusion, 15th day, 30th day and 3rd month |
| Barratt Impulsivity Scale | Inclusion and 3rd month |
| Global Assessment Scale | Inclusion and 3rd month |
| Symptom Check List - 90 | Inclusion, 15th day, 30th day and 3rd month |
Countries
France
Outcome results
None listed