Corneal Endothelium Cell Loss After Cataract Extraction in Patients Taking Tamsulosin

Corneal Endothelium Cell Loss After Cataract Extraction in Patients Taking Systemic Sympathetic Alfa-1-a-antagonist Medication (Tamsulosin)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01076309

Enrollment

Registered

2010-02-26

Start date

2009-06-30

Completion date

2010-09-30

Last updated

2011-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cataract

Keywords

cataract surgery, tamsulosin, endothelium cell

Brief summary

The purpose of this study is to determine whether corneal endothelium cell loss during cataract surgery is higher in patients taking Tamsulosin.

Detailed description

Cataract surgery in patients taking Tamsulosin is regarded as more challenging for the surgeon because Intraoperative Floppy Iris Syndrome (IFIS) might occur. However, the question is whether this has any practical implication for the outcomes of surgery. In this study we investigate whether cornea is damage during surgery on Tamsulosin patient. In an observational study 30 cataract patients taking Tamsulosin is compared to 30 patients not taking Tamsulosin, but otherwise similar. Number of patients is based on power calculation. Cornea is examined by specular microscopy.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Healthy volunteers

Inclusion criteria

* cataract needing surgery

Exclusion criteria

* glaucoma * corneal scarring * diabetes * uveitis

Design outcomes

Primary

Measure	Time frame	Description
corneal endothelium cell loss	3 months	Corneal endothelium cells was evaluated by specular microskopy before and 3 month post-operatively.

Countries

Denmark

Outcome results