The Effects of C-type Natriuretic Peptide on Human Forearm Blood Vessels

The Effects of C-type Natriuretic Peptide on Endothelial Function Following Ischaemia-Reperfusion in the Human Forearm

Status

Withdrawn

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01075776

Enrollment

Registered

2010-02-25

Start date

2020-01-31

Completion date

2023-01-31

Last updated

2020-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischaemia-reperfusion (IR) Injury

Brief summary

To determine the effects of whether increasing CNP concentrations slightly above normal will improve the functioning of blood vessels after the interruption in the flow of blood. In this study we are looking at the function of the blood vessels of the forearm, as a substitute for those in the heart

Interventions

DRUGSaline

Sodium Chloride 0.9% intra-arterially 0.5ml/min

DRUGAcetylcholine

2 stepped infusions for a total 9min per limb, totalling 1.05micromoles per limb

DRUGC-type natriuretic peptide (CNP)

360 pmol/min for 15 minutes intra-arterially

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 45 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy human volunteers on no systemic medication, excepting the oral contraceptive pill

Exclusion criteria

* History of medical illness * Unwillingness to sign consent form * Use of non-OCP medications * Hypertension on examination of the blood pressure

Design outcomes

Primary

Measure	Time frame
Change in area under curve dose-response to acetylcholine after IR injury	2h

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026