Male Infertility
Conditions
Keywords
sperm, male infertility, Carnitine, food supplementation, insemination
Brief summary
Many cases of male infertility are poorly understood and regarded as unexplained. Therefore, a etiological treatment for this condition can not be offered in most cases. A beneficial effect on sperm motility was found in trails using antioxidants such as carnitine, zinc and folic acid. However, most studies lacked a sufficient power to detect a significant effect on pregnancy rates. In this study, infertile men with abnormal sperm quality parameters will be randomized to receive either carnitine-based food supplement (Porimore) or folate and Zinc Tablets.
Interventions
DIETARY_SUPPLEMENTPorimore - A Carnitine based food supplement
A daily dose of 2 grams L-carnitine, 1 gr acetyl L-carnitine, 500mg Vitamin C, 400 IU vitamin E, 60 mg Q10, 30mg Zinc Picolinate, 500mcg Folic Acid, 200 Mcg Selenium, 100 MCG Vitamin B12.
DIETARY_SUPPLEMENTZinc and Folate Supplementation
500 Mcg Folic acid, 30-60 mg Zinc tablets/ day
Sponsors
Shaare Zedek Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* infertility * at least one abnormal sperm quality parameter * female age \< 35 * normal ovarian reserve
Exclusion criteria
* known allergy to one of the food additives planned for treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pregnancy Rate | 3 Insemination cycles | proportion of women becoming pregnancy following treatment with intrauterine insemination |
Secondary
| Measure | Time frame |
|---|---|
| Sperm quality parameters | 3 months |
Countries
Israel
Contacts
Primary ContactAvi Tsafrir, MD
Outcome results
None listed