Healthy
Conditions
Keywords
Congenital mirror movement, physiopathology, imaging, transcranial magnetic stimulation, candidate gene
Brief summary
Mirror movements are involuntary, symmetrical and simultaneous movements occurring on one side of the body that accompany controlateral voluntary movements. Congenital mirror movements (CMM) are characterized by childhood onset and the absence of additional manifestations. The aim of this study is to unravel the pathophysiology of the CMM that remains poorly elucidated. The combination of imaging studies and neurophysiological studies using transcranial magnetic stimulation in a homogeneous and relatively large group of patient is likely to allow us to better understand the underlying pathophysiology of the disorder. Using a linkage analysis approach we will try to identify a locus associated with CMM and related candidate genes.
Interventions
OTHERhealthy volunteers
morphological and functional brain MRI; transcranial magnetic stimulation
OTHERKallmann
morphological and functional brain MRI; transcranial magnetic stimulation
OTHERCongenital Mirror Movement
morphological and functional brain MRI; transcranial magnetic stimulation
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
11 Years to 82 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients aged from 11 to 82 years * Members of the family of interest displaying mirror movements or being obligatory asymptomatic carrier, without additional manifestation or malformation; or patient with genetically proven Kallmann syndrome and mirror movements. * No contraindication for MRI or TMS study
Exclusion criteria
* inability to provide an informed consent * Simultaneous participation in another clinical trial * Treatment that modulate cortical excitability (for the TMS part of the study only)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - To unravel the pathophysiology of congenital mirror movements - To identify a locus and candidate genes associated with CMM | 08/2011 |
Secondary
| Measure | Time frame |
|---|---|
| - To study patients with Kallmann syndrome and associated MM based on the same methods and hypothesis | 08/2011 |
Countries
France
Outcome results
None listed