Hypertension, Pre-hypertension
Conditions
Keywords
Pre-hypertension, Hypertension
Brief summary
The goal of this study is to compare the effects of Potassium Magnesium Citrate to Potassium Chloride on blood pressure among patients with pre-hypertension or mild hypertension. We will also test whether Potassium Magnesium Citrate increases excretion of large amounts of sodium in the urine.
Interventions
DRUGPotassium, Magnesium, Citrate
Potassium MAgnesium Citrate - 30 mEq potassium, 15 mEq Magnesium, 45 mEq Citrate in a powder mixture twice a day, mixed with a glass of water.
DRUGPotassium Chloride
Potassium Chloride
Sponsors
University of Texas Southwestern Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
21 Years to 95 Years
Healthy volunteers
Yes
Inclusion criteria
* Age greater than 21 years * BMI \> 18.5 kg/m2 and \< 40 kg/m2 * Prehypertension and mild hypertension: BP systolic 120-159 mmHg, diastolic 80-95 mmHg * Must agree to limit lifestyle changes including: 1) embarking on a new exercise or weight reduction program 2) altering alcohol intake during the trial.
Exclusion criteria
* Taking blood pressure lowering medication * Diabetes mellitus * Renal disease * Active cardiac disease * Active liver disease * Chronic diarrhea * Chronic NSAID use * Active or suspected drug use * Uncontrolled psychiatric disease * HIV infection * Missed more than 20% of clinic visits in the last yr * Prescription of diuretics for any reason * A patient taking nutritional supplements including multivitamins that is unwilling to discontinue them,\\ * Consumption of greater than 14 alcoholic beverages per week
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood Pressure | 8 weeks | We have estimated to detect a 4 mmHg difference, with a standard deviation estimated at 8 mmHg. |
Countries
United States
Outcome results
None listed