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Neurally Adjusted Ventilatory Assist for Non Invasive Ventilation and Patient-ventilator Interaction

The Effects of Neurally Adjusted Ventilatory Assist (NAVA) on Improving Patient-ventilator Interaction in Patients Undergoing Ventilation for Acute Respiratory Failure

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01074866
Enrollment
13
Registered
2010-02-24
Start date
2010-07-31
Completion date
2011-12-31
Last updated
2012-09-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non Invasive Ventilation, Patient Ventilator Interaction

Keywords

Mechanical ventilation, Non invasive Ventilation, Patient-ventilator interaction, Pressure support, Neurally adjusted ventilatory assist

Brief summary

The present study aims to compare various parameters reflecting patient-ventilator synchrony during standard pressure support (PS) and Neurally Adjusted Ventilatory assist (NAVA) in a group of patients receiving non invasive ventilation (NIV)for an episode of acute respiratory failure of various origin.

Detailed description

The present study aims to compare various parameters reflecting patient-ventilator synchrony during standard pressure support (PS) and Neurally Adjusted Ventilatory assist (NAVA) in a group of patients receiving non invasive ventilation (NIV)for an episode of acute respiratory failure of various origin. The subgroup of COPD patients will be analyzed separately. The effects of various setting of Neurally adjusted ventilatory assist on patient-ventilator interaction will also be explored.

Interventions

DEVICENeurally Adjusted Ventilatory Assist

Non invasive ventilation under Neurally adjusted Ventilatory Assist

Sponsors

University Hospital St Luc, Brussels
CollaboratorOTHER
University Hospital Sart Tilman, Liege
CollaboratorUNKNOWN
University of Lausanne Hospitals
CollaboratorOTHER
Notre Dame de Grace Hospital, Gosselies
CollaboratorUNKNOWN
University Hospital, Geneva
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No

Inclusion criteria

* Patients admitted to the ICU and treated with Non invasive ventilation for acute respiratory failure of any origin

Exclusion criteria

* severe hypoxemia requiring an FIO2\>0.6 * hemodynamic instability * known oesophageal problem * active upper gastro-intestinal bleeding * any other contraindication to the insertion of a naso-gastric tube * impaired consciousness or absence of patient cooperation * facial or laryngeal lesions contraindicating the use of NIV * poor short term prognosis

Design outcomes

Primary

MeasureTime frame
Patient-ventilator synchronization parameters—

Countries

Belgium, Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026