Contrast Enhanced Ultrasonography (CEUS) of Patients With Crohn's Disease

High Frequency Ultrasound and Contrast Enhanced Ultrasound of Patients Treated for Deterioration of Crohn's Disease

Status

Terminated

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01074580

Enrollment

Registered

2010-02-24

Start date

2009-11-30

Completion date

2013-12-31

Last updated

2016-01-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Crohn's Disease

Keywords

Crohn's disease, sonography, contrast enhanced ultrasound

Brief summary

The purpose of this study is investigate if high frequency sonography and contrast enhanced sonography can be used to predict remission in patients with deterioration of Crohn's disease treated with steroids or tumor necrosis factor (TNF) alfa inhibitors.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Deterioration of Crohn's disease * CDAI\>150 * Treated with systemic steroids or TNF alfa inhibitors * Lesion found on ultrasound

Exclusion criteria

* Disease location not reachable with ileocolonoscopy * Pregnancy * Acute coronary disease * Unstable coronary disease * Previous allergic reaction to SonoVue or its components

Design outcomes

Primary

Measure	Time frame
Remission defined by Crohns disease activity index (CDAI)<150	52 weeks from inclusion

Secondary

Measure	Time frame
Surgical treatment for Crohn's disease during follow up. (Surgery for perianal disease not included.)	52 weeks
Mucosal healing on ileocolonoscopy. Defined by Simple Endoscopic Index for Crohn's disease (SES-CD)	12 weeks

Countries

Norway

Outcome results