Vitamin D Status
Conditions
Keywords
Vitamin D, UVB, Dose-Response, UV intensity, Skin cancer
Brief summary
The purpose of the study is to determine the importance of the UV intensity and the UVB dose on the Vitamin D response after UVB.
Detailed description
The work is addressing vitamin D production after UVB exposure and explore the importance of UVB dose and UV intensity. Four different UVB doses and four different UV intensities are used to explore these relationships. Many assumptions have been made concerning the vitamin D production after UVB exposure but only few studies exist.
Interventions
RADIATIONUVB
0.375 SED x 4 in a week
Sponsors
The Danish Medical Research Council
Bispebjerg Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-65 years * Healthy
Exclusion criteria
* Sun bed use * Holiday or business travel south of 45 degrees latitude during trial * Illness * Drug addiction * Pregnancy * Lactating
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vitamin D (nmol/l) | 2 days after exposure | Vitamin D measured in a blood sample to define the dose-response relationship between UVB dose, UV intensity and Vitamin D production in the skin after UVB exposure. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Other parameters | 2 days after radiation | To invesitage whether other parameters like sex, BMI, Diet etc. influences the vitamin D production after UVB exposure. |
Countries
Denmark
Outcome results
None listed