Dental Anesthesia Efficacy
Conditions
Keywords
Liposome, Prilocaine, Dental anesthesia
Brief summary
This blinded randomized, crossover, three period study aim to evaluate the anesthetic efficacy of liposome-encapsulated 3% prilocaine compared to 3% plain prilocaine and 3% prilocaine with 0,03IU/mL felypressin, after 1.8mL infiltration in the buccal sulcus of the maxillary right canine, in 32 volunteers.
Interventions
DRUGPrilocaine
1.8mL infiltration of liposome-encapsulated 3% prilocaine, 3% plain prilocaine or 3% prilocaine with 0,03IU/mL felypressin in the buccal sulcus of the maxillary right canine
Sponsors
Fundação de Amparo à Pesquisa do Estado de São Paulo
Conselho Nacional de Desenvolvimento Científico e Tecnológico
University of Campinas, Brazil
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* good health * no history of allergy to the components of the local anesthetic formulations tested * maxillary canine, lateral incisor, and first premolar responsible to electric stimulation
Exclusion criteria
* intake of any medication that would alter pain perception * history of trauma or sensitivity, caries, restorations, periodontal disease and endodontic treatment in the maxillary canine, lateral incisor, and first premolar * systemic disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anesthesia success, onset and duration of pulpal and gingival anesthesia. | 10 minutes |
Secondary
| Measure | Time frame |
|---|---|
| Injection pain - Visual Analogue Scale | 1 minute after the injections |
Countries
Brazil
Outcome results
None listed