Comparison of Hyperemic Efficacy Between Central and Peripheral Adenosine Infusion for Fractional Flow Reserve (FFR) Measurement

Conditions

Coronary Artery Disease, Myocardial Ischemia

Keywords

Adenosine, Fractional flow reserve, Hyperemia, Fractional Flow Reserve, Myocardial

Brief summary

The purpose of this study is to evaluate the safety and effectiveness of the peripheral IV continuous infusion without the insertion of central venous vascular access method in the achievement of steady-state maximal coronary hyperemia compared with the central IV continuous infusion method.

Park DW, Kim YH, Song HG, Ahn JM, Kim WJ, Lee JY, Kang SJ, Lee SW, Lee CW, Park SW, Yun SC, Her SH, Hur SH, Park JS, Kim MK, Choi YS, Kim HS, Cho JH, Lee SG, Park YW, Jeong MH, Lee BK, Lee NH, Lim DS, Yoon J, Seung KB, Shin WY, Rha SW, Kim KS, Tahk SJ, Park BE, Ahn T, Yang JY, Jeong YS, Rhew JH, Park SJ, IRIS-DES Investigators.

2012-06-1236 citations

10.1161/circinterventions.111.966549

Comparison of hyperemic efficacy between central and peripheral venous adenosine infusion for fractional flow reserve measurement.

Seo MK, Koo BK, Kim JH, Shin DH, Yang HM, Park KW, Lee HY, Kang HJ, Kim HS, Oh BH, Park YB.

2012-05-2945 citations

10.1161/circinterventions.111.965392

Interventions

OTHERFFR via central venous line

Patients with intermediate coronary artery stenosis were consecutively enrolled. FFR was measured by a standard intravenous (IV) adenosine infusion (140 μg•min-1•kg-1) via Rt central femoral vein.

OTHERFFR via peripheral venous line

Patients with intermediate coronary artery stenosis were consecutively enrolled. FFR was measured by a standard intravenous (IV) adenosine infusion (140 μg•min-1•kg-1) via continuous peripheral vein.

Study design

Allocation

NON_RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

DIAGNOSTIC

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Healthy volunteers

No

Inclusion criteria

* non -infarct related, patients with moderate coronary artery stenosis * normal ejection fraction on echocardiogram

Exclusion criteria

* infarct-related arteries or clinically unstable state * collateral blood flow to the target vessel is shown * atrioventricular block on electrocardiogram * reduced ejection fraction(\<50%) or left ventricular hypertrophy on echocardiography * contraindication of adenosine

Design outcomes

Primary

Measure	Time frame
compare fractional flow reserve at maximal hyperemia	interval of 10 minutes

Secondary

Measure	Time frame
compare the time to maximal hyperemia and changes in heart rate	interval of 10 minutes

Countries

South Korea

Outcome results

None listed