Wheat Allergy
Conditions
Keywords
skin test, open wheat challenge
Brief summary
Nowadays, commercial wheat extract is widely accessible, and is used for skin prick test for wheat allergy. However, commercial wheat extracted for skin prick test have less precise test result compared to extract from omega-5 gliadin, which is one of the major allergen with immediate wheat allergy.
Interventions
OTHERCommercial extract and in-house wheat extract
Patients with a history of wheat allergy underwent two skin test extracts, and open challenge with wheat. A blood test for specific IgE was performed in the same time.
Sponsors
Mahidol University
Study design
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Years to 15 Years
Healthy volunteers
No
Inclusion criteria
* A patient with the age of 1-15 year old * A history of symptoms that suspected of type 1 hypersensitivity (eg. Urticaria, angioedema, wheezing, anaphylaxis) occur within 4 hours after wheat ingestion. * Patients attend in allergy clinic, pediatric department, Siriraj hospital since 2007-2012
Exclusion criteria
* First sign and symptom happens more than 4 hours since wheat ingestion * Have underlying disease such as heart disease, epilepsy etc. * Have contraindication for performed skin prick test
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| correlation skin test result and food challenge result | 3 year |
Secondary
| Measure | Time frame |
|---|---|
| comparison of skin test result and specific IgE to challenge result | 3 year |
Countries
Thailand
Outcome results
None listed