Postoperative Pain Management
Conditions
Keywords
Preemption, ketamine, escalating, dose, pain, analgesia
Brief summary
Ketamine affects postoperative pain when administered intravenously immediately before, during or at the end of surgical procedures. We assessed the effects of multiple and escalating doses of ketamine administered many hours before surgery on postoperative pain and analgesia consumption.
Interventions
DRUGKetamine
group receiving one injection (25 mg) of ketamine (K1) intramuscularly (IM) at 3-4 hours before surgery or placebo (saline 0.9%, NS)
DRUGketamine
ketamine at 11-12 hours (10 mg) and 3-4 hours (25 mg) before surgery (K2), with a corresponding NS group
Sponsors
Tel-Aviv Sourasky Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
15 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Consecutive patients, who were scheduled to undergo general or orthopedic oncologic surgery under general anesthesia
Exclusion criteria
1. allergy to opioids, ketamine or non-steroidal anti-inflammatory drugs (NSAIDs) 2. history of lasting chronic pain or psychiatric disorders or had used opioids or psychotropic drugs of any sort during the past two weeks 3. soldiers and pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative pain | 48 hours |
Secondary
| Measure | Time frame |
|---|---|
| opioid drug consumption | 48 hours |
Countries
Israel
Outcome results
None listed