Chronic Lymphocytic Leukemia
Conditions
Keywords
Chronic Lymphocytic Leukemia, CLL, Normal Volunteers
Brief summary
The purpose of this study is to collect a blood sample from patients with Chronic Lymphocytic Leukemia (CLL) and from volunteers without CLL.
Detailed description
The blood sample will be used in the laboratory to perform focused studies on Chronic Lymphocytic Leukemia (CLL).
Interventions
OTHERNo Intervention
No Intervention
Sponsors
Dartmouth-Hitchcock Medical Center
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients undergoing routine blood draws as part of their ongoing follow-up care for CLL at the Norris Cotton Cancer Center of DHMC. * Normal donors who have no history of active or prior hematologic malignancy.
Exclusion criteria
* Patients who have received cytotoxic drug, oral or intravenous steroid or targeted antibody therapy for their CLL, other hematologic malignancy or other disease process within the past 2 months are excluded. Use of intravenous immunoglobulin (IVIg) is not a reason for exclusion. * Normal donors who have a history of steroid use, immunosuppression therapy or autoimmune disease are excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To identify the genes that are differentially expressed at the polysomal RNA and protein levels in human patient CLL cells (compared to normal donor lymphocytes) using high-throughput microarray approaches. | 2 Years |
Secondary
| Measure | Time frame |
|---|---|
| To determine whether the novel candidate genes from Specific Aim 1 have potential roles in CLL. (Note: Specific Aim 2 does not involve human subjects research). | 2 Years |
Countries
United States
Outcome results
None listed