Subfertility
Conditions
Brief summary
This observational study attempts to investigate the potential role of serum progesterone levels on the day of hCG administration (thus, the end of the follicular phase) on the probability of pregnancy, in patients undergoing IVF with the use of GnRH antagonists and recombinant gonadotrophins. There has been evidence, that increased serum levels of progesterone are associated with a decreased probability of pregnancy after IVF. This study will attempt to explore the role of progesterone on the outcome of IVF, by closely monitoring its levels during the late follicular phase.
Interventions
None listed
Sponsors
Aristotle University Of Thessaloniki
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 39 Years
Healthy volunteers
No
Inclusion criteria
* Age \< 40 years * Basal FSH \< 12 IU/L * Basal P \< 1.6 ng/mL
Exclusion criteria
* Presence of cystic formations at the ovaries during the basal ultrasound scan (prior the initiation of stimulation) * Women with polycystic ovaries syndrome (PCOS) * Women with Stage III-IV Endometriosis * Women with a pathological condition of the adrenal glands
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy, defined as ultrasound evidence of fetal heart activity at 6-8 weeks of gestation | At 6-8 weeks of gestation |
Secondary
| Measure | Time frame |
|---|---|
| Pregnancy (defined as a b-hCG> 25 IU/L) | 12 days after embryo transfer |
Countries
Greece
Outcome results
None listed