Cardiovascular Risk, Obesity
Conditions
Keywords
Obesity, overweight, childhood, adolescence, inpatient therapy, lifestyle intervention, cardiovascular risk, gene-lifestyle-interaction, Obesity and associated cardiovascular risk in childhood and adolescence,, health behaviour
Brief summary
The purpose of the study is to determine the genetic influence on short-, middle- and longterm effects of an inpatient lifestyle therapy program in overweight and obese children and adolescents.
Detailed description
In Germany, as in other countries, overweight and obesity affects a growing number of children and adolescents. Obesity-related diseases such as arterial hypertension, disorders of glucose and lipid metabolism and an increase in inflammation markers are associated with higher morbidity and mortality in early life, therefore effective therapy concepts are needed. The aim of this study is to evaluate the effects of a 4-6 week inpatient obesity lifestyle therapy program over 10 years and the genetic influence on the short-, middle- and longterm outcome. The lifestyle intervention consists of physical exercise, nutrition education and behaviour therapy based on the criterions developed by the German Obesity Group (degree of weight reduction, improvement of comorbidity and health behaviour, minimising of side effects).
Interventions
BEHAVIORALLOGIC
Experimental group: Diet (1200-1800 kcal/d), Exercise: 11 h/wk physical activity, Behavioural therapy (group training, 1-3h/wk individualized personal instructions, 2 h parents work)
Sponsors
Rehabilitation clinic Schönsicht, 83471 Berchtesgaden
Technical University of Munich
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
6 Years to 19 Years
Healthy volunteers
Yes
Inclusion criteria
* Overweight or obese children (BMI \>90th percentile for age and gender), who obtained an inpatient lifestyle intervention in the participating clinic. * Children with written consent from their parents and the acceptance of a 10-year follow-up.
Exclusion criteria
* Children without written consent from their parents. * Children with monogenetic diseases with influence on obesity (e.g. Prader-Willi-Syndrome) or with secondary obesity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Influence of gene variants in FTO, MC4R and TMEM-18 on reduction of overweight and obesity measured by standard deviation score Body Mass Index (sds-BMI) | 16 years |
Countries
Germany
Outcome results
None listed