Patient Between 1-8 Years Old Undergoing Elective Surgery at Queen Mary Hospital
Conditions
Brief summary
Intranasal dexmedetomidine has shown to be an effective sedative when used prior to anaesthetic induction as premedication. 1mcg/kg intranasal dexmedetomidine was used in previous study and it produced satisfactory sedation in more than 50% of the children at the time of anaesthetic induction with no adverse effect. In this study we aim to compare 1mcg/kg with 2mcg/kg intranasal dexmedetomidine in children. We expect more children would attain satisfactory sedation prior to anaesthetic induction when higher dose is used.
Interventions
DRUGDexmedetomidine
Intranasal dexmedetomidine is given as premedication prior to induction of anesthesia
Sponsors
The University of Hong Kong
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
1 Years to 8 Years
Healthy volunteers
No
Inclusion criteria
* Age 1-12 years old * American Society of Anesthesiologists (ASA) 1-2 * Elective surgery * Children with autism or pervasive personality disorder
Exclusion criteria
* American Society of Anaesthesiologists (ASA) 3-5 * Allergy or hypersensitive reaction to dexmedetomidine * Known cardiac arrhythmia or congenital heart disease * Mentally disabled
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| proportion of children attained satisfactory sedation | one hour |
Secondary
| Measure | Time frame |
|---|---|
| time to onset of sedation | one hour |
Countries
Hong Kong
Outcome results
None listed