Chronic Hepatitis B
Conditions
Keywords
Hepatitis B virus DNA, Metabolic factor, Body mass index, Obesity, Insulin resistance, Lifestyle factor, Preventive Medicine, Health Promotion
Brief summary
The investigators propose a project of preventive medicine with concern of local context in Taiwan. The target population includes all staff and faculty members, students, and alumni of a university in Northern Taiwan, with chronic hepatitis B infection. The intervention of this project includes standardized lectures, sports courses, nutrition courses, and an information platform. The investigators will evaluate the efficacy after the intervention, like the reduction of hepatitis B viral load and the associated anthropometric parameters. The results of this project will be initially served as a pilot study for this cohort, and applicated as a promising basis for health promotion.
Interventions
BEHAVIORALstandardized exercise program and dietary counseling
Lecture, 12 weeks Standardized exercise program, 12 weeks Dietary counseling, 12 weeks Information platform, 12 weeks
Sponsors
National Taiwan University
National Taiwan University Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Participants were recruited from students, alumni, faculty and staff members with chronic HBV infection (positive HBsAg serostatus ≥6 months) in a university of northern Taiwan from August 1, 2009 to July 01, 2010. Only participants aged 18 and older were included.
Exclusion criteria
* Excluded were: * (a) those who had been diagnosed as chronic liver diseases like chronic hepatitis C infection (Anti-HCV (+)), autoimmune hepatitis, Wilson disease, alcoholic liver diseases, drug-related hepatitis, decompensated liver diseases, cirrhosis, or malignant hepatic tumors; * (b) those who had undergone liver transplantation or major operations for liver except cholecystectomy; * (c) men who consumed more than 30 gram of alcohol per week or women who consumed more than 20 gram of alcohol per week; * (d) women who were pregnant; * (e) those who had current medications for any types of chronic diseases except for hyperglycemia, elevated blood pressure, or dyslipidemia within six months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of relative serum HBV DNA levels | three months |
Secondary
| Measure | Time frame |
|---|---|
| anthropometric index | three months |
Countries
Taiwan
Outcome results
None listed