Chronic Major Depression
Conditions
Keywords
Depressive Disorder, Psychotherapy
Brief summary
The propose of the study is to investigate the efficacy of Mindfulness-based Cognitive Therapy (MBCT, Segal, Williams, & Teasdale, 2002) for patients suffering from Chronic Major Depression. The efficacy of MBCT will be compared with the Cognitive Behavioral Analysis System of Psychotherapy (McCullough, 2003), a treatment approach, which has proven it's efficacy yet, and with a treatment-as-usual condition (standard psychiatric outpatient care).
Detailed description
Cognitive Behavioral Analysis System of Psychotherapy (CBASP) is a treatment approach specifically developed for the treatment of chronic depression. CBASP aims to change dysfunctional interpersonal patterns. Mindfulness-based Cognitive Therapy (MBCT) has recently been proposed as a further treatment option for chronic depression. MBCT trains patients to step out of negative ruminative states of mind. There are no direct comparisons of the psychological treatment options for chronic depression.
Interventions
BEHAVIORALMindfulness-based Cognitive Therapy
Mindfulness-based Cognitive Therapy is based on an integration of aspects of cognitive behavioral therapy for depression (Beck et al., 1979) with components of the Mindfulness-based Stress Reduction program developed by Kabat-Zinn and colleagues (Kabat-Zinn, 1990). After an initial orientation session, the MBCT program is delivered by an instructor in eight weekly 2.5 hr group sessions
BEHAVIORALThe Cognitive Behavioral Analysis System of Psychotherapy
The Cognitive Behavioral Analysis System of Psychotherapy integrates behavioral, cognitive, and interpersonal strategies. After two initial orientation sessions, the MBCT program is delivered weekly by an instructor in eight 2.5 hr group sessions.
BIOLOGICALStandard psychiatric care
Antidepressant medication and medical care. Standard psychiatric outpatient care: All patients were requested to get treated individually either by a psychiatrist or by a licensed psychotherapist (not member of the study team). If patients were already in psychiatric/psychotherapeutic individual treatment at study intake they continued their treatment with this psychiatrist/psychotherapist
Sponsors
Johannes Michalak
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Clinical diagnoses of Major Depression, single episode, chronic or * Major Depression, recurrent, chronic * Hamilton Rating Scale for Depression score \> 14 * Beck Depression Inventory II score \> 14
Exclusion criteria
* History of Schizophrenia or Schizoaffective Disorder * Current Substance Dependence or Eating Disorder * Mental Disorder Due to General Medical Condition * Borderline Personality Disorder
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Rating Scale for Depression | Change from Baseline in HAM-D at 8 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Beck Depression Inventory II | Change from Baseline in BDI-II at 8 weeks |
| Social Adaption Self-evaluation Scale | Change from Baseline in SASS at 8 weeks |
| Short Form (36) Health Survey | Change from Baseline in SF-36 at 8 weeks |
| Global Assessment of Functioning Scale | Change from Baseline in HAM-D at 8 weeks |
| Response Styles Questionnaire | Change from Baseline in RSQ at 8 weeks |
Countries
Germany
Outcome results
None listed