Alcoholic Cirrhosis
Conditions
Brief summary
Hepatocellular carcinoma (HCC) is a frequent complication of cirrhosis. Occurrence of HCC could be linked with multiple functional region of genome. The determining of a genomic mapping of single nucleotide polymorphisms (SNPs) permit to perform some genetic link studies with pathologies without clear hereditary disposition. In this study, the investigators will identify predictives genetic polymorphism of HCC.
Interventions
GENETICDNA extraction
DNA extraction of blood sample for DNAship analysis
Sponsors
Nantes University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
35 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* 35 to 70 years old * Compensated cirrhosis or not * Caucasian origin of the parents * Patient with cirrhosis (histological proof or obvious)
Exclusion criteria
* HIV, HBV, HCV positive * Known Homozygotia (C282Y+/+) * Important hepatocytary iron overload for patient with resection * HCC non histologically prooved
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Existence of HCC and Pangenomic analysis of DNA polymorphism | — | Existence of HCC and determination of which genetic polymorphism are predisposing to HCC or preventing for HCC |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| cirrhosis severity (compensated or not) | — | Analysis of the genetic polymorphism involved in the severity of cirrhosis |
Countries
France
Outcome results
None listed