Infertility
Conditions
Keywords
hCG, Treg cells, implantation, pinopodes, endometrium
Brief summary
Intrauterine injection of hCG around the time of implantation may increase endometrial Treg cells and improve implantation. It has been demonstrated that regulatory T cells expand during pregnancy. hCG was found to be secreted by the embryo immediately after fertilization and has chemoattractant properties to Treg cells.
Detailed description
Aim of the work: To study the effect of intrauterine injection of human chorionic gonadotrophin on the endometrial T regulatory cells (Treg cells)and the electromicroscopic endometrial characteristics. Background: It has been demonstrated that regulatory T cells expand during pregnancy and are present at the feto-maternal interface at very early stages in pregnancy. Rational: Intrauterine injection of hCG around the time of implantation may increase endometrial Treg cells and improve implantation. Methods: Intrauterine injection of 100 IU hCG will be done followed by endometrial biopsy to check for Treg cells and pinopodes.
Interventions
intrauterine injection of 100 IU hCG followed by endometrial biopsy .
Sponsors
The Egyptian IVF-ET Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 38 Years
Healthy volunteers
No
Inclusion criteria
* Male factor infertility * Ovulatory factor infertility * Unexplained infertility * Female age less than 39
Exclusion criteria
* Azoospermia * Tubal factor infertility * Pelvic endometriosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the presence of Treg cells and pinopodes in the endometrium | 4 weeks |
Secondary
| Measure | Time frame |
|---|---|
| pregnancy rate | 4 weeks |
Countries
Egypt
Outcome results
None listed