Prospective Assessment of Adolescent Drinking Trajectories With Computer-Assisted Self-administration of Ethanol (CASE)

Collaboration on Alcohol Self Administration in Adolescents and Young Adults - Specific Aim 1: Assess the Initial Slope of Adolescent Drinking Trajectories, Beginning at the Age of Eighteen

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01063166

Enrollment

Registered

2010-02-05

Start date

2010-06-30

Completion date

2015-12-31

Last updated

2016-01-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alcoholism

Brief summary

The Computer-Assisted Self-administration of Ethanol (CASE)will be administered twice, at the ages 18 and 20, in a prospective study of 80 adolescents living in the Dresden area. The sample will be recruited for a differential family history of alcoholism (FHA) and gender, with inventories of alcohol use disorder (AUD) symptoms and personal recent drinking history (RDH) obtained prior to each CASE session.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 19 Years

Healthy volunteers

Yes

Inclusion criteria

* (a) male and female Caucasian volunteers aged 18 years/0 months to 19 years/11 months; * (b) written informed consent by the subject; * (c) habitual social drinking during the two months preceding participation, defined by at least one drinking day in any two weeks-interval; * (d) at least one prior experience of alcohol intoxication * (e) being able to abstain from tobacco use for four hours without developing nicotine withdrawal symptoms; * (f) effective contraception in female participants; * (g) consenting to abstain from any illegal substance use for 2 weeks prior to participation; * (h) living within 15 km (9.5 miles) from downtown Dresden; * (i) sufficient information concerning alcohol use in both parents and in at least four second-degree relatives

Exclusion criteria

* (a) prior medical treatment due to alcohol use; * (b) current or prior history of any serious disease, including CNS, cardiovascular, respiratory, gastrointestinal, hepatic, renal, endocrine, alcohol or drug dependence, but not alcohol abuse; * (c) current history of Axis-I psychiatric illness, including premenstrual dysphoric disorder; * (d) current or prior history of alcohol-induced flushing reactions; * (e) positive urine screen for cannabinoids, cocaine, amphetamines, opiates, or benzodiazepines; * (f) light or non-drinkers: averaging less than 2 standard drinks per week in the preceding two months; * (g) intention to become pregnant * (h) pregnancy or positive urine pregnancy screening or breast-feeding; * (i) any alcohol intake on the test day or the day before; * (k) use of medications known to interact with alcohol within 2 weeks of the study; * (l) positive hepatitis or HIV at screening, provided the subject consented to these tests

Design outcomes

Primary

Measure	Time frame	Description
Alcohol consumption	2 years	Alcohol consumption, as measured by a Timeline Followback Interview and experimental Self-Administration.

Secondary

Measure	Time frame
Alcohol Use Disorders	2 years

Countries

Germany

Outcome results