Opioid Consumption, Postoperative Pain
Conditions
Keywords
intravenous lidocaine, postoperative pain, laparoscopic surgery, opioids, opioids side-effects
Brief summary
Intravenous lidocaine has been shown to have analgesic, antinflammatory, antihyperalgesic, antithrombotics and neuroprotective properties. In a previous study conducted in patients undergoing laparoscopic cholecystectomy under general anesthesia with desflurane and fentanyl, intraoperative i.v. infusion of lidocaine spared opioids consumption in the recovery room by 30%. The purpose of this study was to determine if an i.v. infusion of lidocaine without intraoperative opioids would reduce the amount of fentanyl to the same extent and opioids-related side effects.
Interventions
DRUGLidocaine
1.5 mg/Kg as bolus and a continuous infusion of 2mg/Kg/hr until the end of surgery (closure of the skin)
DRUGFentanyl
Fentanyl 3 mcg/Kg as bolus at the induction and a continuous infusion of normal saline (NaCl 0.9%) until the end of surgery (skin closure)
Sponsors
McGill University Health Centre/Research Institute of the McGill University Health Centre
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* patients undergoing laparoscopic cholecystectomy
Exclusion criteria
* age \<18 yr or \> 85 yr, * ASA physical status 3 and greater, history of hepatic failure (Child & Pug A-C), * renal failure (creatinine outside the normal range) or cardiac failure (NYHA I-IV), * Adams-Stoke syndrome, * severe degrees of sinoatrial, atrioventricular or intraventricular block, * organ transplant, * diabetes mellitus type 1 and 2, * morbid obesity (BMI \> 40), * chronic use of opioids and beta-blockers, * known seizures, * severe mental impairment, * allergy to local anesthetics and to all the medications used in the study, or * inability to understand pain assessment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fentanyl consumption (measured as fentanyl equivalents -mcg) | postoperative day 0 (day of surgery before beeing discharged home) and 24 hr after the end of surgery |
Secondary
| Measure | Time frame |
|---|---|
| Pain, Static and Dynamic | On postoperative day 0 (day of surgey before beeing discharged home) and 24 hrs after the end of surgery |
| Opioids side-effects | On postoperative day 0 (before beeing discharged home) and at 24 hrs after the end of surgery |
Countries
Canada
Outcome results
None listed