Functional Neuroimaging of Cortical Plasticity in the Human Visual System

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01062672

Enrollment

Registered

2010-02-04

Start date

2009-01-31

Completion date

2015-12-31

Last updated

2022-04-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Blindness, Stroke, Vision

Keywords

plasticity, reorganization, cortical, fMRI, rehabilitation

Brief summary

The study's objective is to measure changes in human visual cortex organization that may arise as a result of injury to the visual pathways. Subjects with retinal or cortical injury will be studied and compared to appropriate controls. Functional magnetic resonance imaging methods are used to monitor cortical topography in time. The main aims of the study are to determine: 1) what are the patterns of cortical reorganization that are seen spontaneously after injury, and 2) whether rehabilitative training can promote adaptive reorganization enhancing recovery.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Stable lesion of the visual pathways resulting in a visual field scotoma.

Exclusion criteria

* Inability to undergo magnetic resonance imaging, * Inability to comply with basic instructions, * Inability to perform the behavioral tasks required, * Patients with chronic progressive neurological or psychiatric disorders, * Patients that are pregnant, or breast feeding.

Countries

Germany, United States

Outcome results