Abdominal Aortic Aneurysm
Conditions
Brief summary
An aneurysm is a permanent and localized dilatation of an artery usually more than 50% of its normal diameter. Abdominal Aortic Aneurysms (AAA) is an aneurysm of the main artery of abdomen and affects 5% of men aged 65-74 years. Rupture of an aneurysm is the 10th leading cause of death in white men over 65 years of age in industrial countries. Treatment of asymptomatic AAA is considered when the diameter of an AAA reaches 5.5 cm. There are two treatment options available: conventional open surgical repair or endovascular repair, which is a less invasive mode of treatment. After the operation heart and lung complications are significant in patients undergoing major abdominal surgery. The commonest causes of death are due to heart problems. There are various studies which have shown benefits of pre operative exercise training in patients undergoing orthopaedic, lung and heart bypass surgery. Currently, there is no data available with regards to the effect of pre-operative (before operation) supervised exercise in patients undergoing surgery for an AAA. The main aim of this study will be to determine whether a pre-operative supervised exercise programme improves post-operative (after operation) outcome, compared to standard treatment. Patients will be entered in the study once a decision to repair their AAA has been made by the consultant. They will undergo pre-operative assessment and will be divided randomly into two groups. One group will have exercise training for 4-6 weeks before surgery and the other will not. After the operation they will be followed during the post-operative period to determine the presence or absence of complications. It is anticipated that complications will be less in the group which has undertaken exercise training before operation.
Interventions
OTHERSupervised exercise
Exercise class, this will be performed three times a week with average duration of 40 minutes for 4-6 weeks.
OTHERRole of exercise
Exercise class, this will be performed three times a week with average duration of 40 minutes for 4-6 weeks.
Exercise class, this will be performed three times a week with average duration of 40 minutes for 4-6 weeks.
Sponsors
Hull University Teaching Hospitals NHS Trust
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients undergoing open repair for an asymptomatic peri-renal and infra-renal abdominal aortic aneurysm. * Patients undergoing Endovascular aneurysm repair (EVAR). * Able to comply with study protocol. * Able to give informed consent.
Exclusion criteria
* Patients with severe disabling disorders limiting mobility for example severe osteoarthritis. * Patients undergoing emergency repair of Abdominal Aortic Aneurysm. * Patients with thoraco abdominal aneurysms. * Patients unable to communicate in English.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite outcome including cardiac, respiratory and renal complications | First three months after intervention |
Secondary
| Measure | Time frame |
|---|---|
| Length of ITU/ HDU stay, length of hospital stay (medical/ total), quality of life scores (SF-8 and EURQOL) & death within 30 days of surgery | First three months after intervention |
Countries
United Kingdom
Outcome results
None listed