Healthy
Conditions
Keywords
patients infected with a bacteria sensible to ertapeneme
Brief summary
Ertapenem is an antibiotic that is highly bound to plasma protein (\> 95%). The effects of this high protein binding on tissue distribution of antibiotics have been few evaluated yet. In this study, two groups of subjects will be compared: 6 healthy volunteers and 6 critically ill patients (patients with infection due to an Ertapenem susceptible bacteria). Indeed, these 2 populations show changes in binding capacity of drugs to plasma proteins due to a decrease of protidaemia and of the affinity of drugs to transport proteins. It seems therefore important to clarify the consequences of a modification in protein binding on distribution of antibiotics. That's why we have decided to characterize tissue distribution of ertapenem in healthy volunteers and critically ill patients by assessing: free and total concentrations in plasma and free concentrations in muscle by microdialysis.
Interventions
DRUGErtapeneme
Sponsors
Poitiers University Hospital
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Age: from 18 to 80 years * Patients with infection due to ertapenem susceptible bacteria.
Exclusion criteria
* Patients who received ertapenem within 7 days prior to inclusion * Known allergy to ertapenem or any excipients * Neutropenia \< 500/mm3 * Hemoglobin concentration \< 9g/dl * Renal failure (creatinin clearance \< 30ml/min/1.73m²) * Decompensated heart failure * Patients receiving vasopressor (adrenalin, noradrenalin), \> 0.5µg/kg/min * Known hypersensitivity to Elma® * Positive pregnancy test or currently lactating
Countries
France
Outcome results
None listed