Study of the Benefit of Exercise and Aminoacid Supplements in Cirrhotic Patients

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01060813

Enrollment

Registered

2010-02-02

Start date

2010-01-31

Completion date

2010-12-31

Last updated

2015-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cirrhosis

Keywords

cirrhosis, exercise, leucin, glutamine synthetase

Brief summary

This is a pilot study including 20 cirrhotic patients that will be randomized to receive during 3 months leucine vs leucine plus a programme of physical exercise specially designed for cirrhotic patients. The hypothesis is that physical exercise in cirrhotic patients could increase muscle mass (and therefore glutamine synthetase activity leading to a higher blood ammonium clearance) and quality of life. Safety of physical exercise in cirrhotic patients will be strictly assessed.

Interventions

DIETARY_SUPPLEMENTLeucine supplements

leucine supplements

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* compensated liver cirrhosis.

Exclusion criteria

* hepatocellular carcinoma, * active alcoholism (less than 1 year), * decompensated cirrhosis, * variceal bleeding less than 3 months, * contraindication for exercise.

Design outcomes

Primary

Measure	Time frame
glutamine synthetase activity	three months

Secondary

Measure	Time frame
quality of life	three months

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026