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Low Energy Availability, Menstrual Irregularity, and Low Bone Mass

The Role of Low Energy Availability and the H-P-A Axis, Menstrual Irregularity, and Low Bone Mass

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT01059968
Enrollment
45
Registered
2010-02-01
Start date
2008-09-30
Completion date
2009-12-31
Last updated
2011-06-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bone Density, Energy Availability

Keywords

bone density, energy availability, menstrual status, female, adolescent

Brief summary

This study examines the role of energy availability on menstrual function and bone mass in female adolescent endurance athletes. Specific evaluations include dietary intake, exercise energy expenditure, training schedules, menstrual function and bone density.

Detailed description

The purpose of this project is to examine the relationships among low energy availability, H-P-A axis, menstrual function and bone density and bone turnover in high school female cross country runners. Our objectives are to: 1)determine energy intake, exercise energy expenditure, and fat-free mass to examine energy availability; 2)in a subset of runners, using double labelled water, estimate total energy expenditure and indirect calorimetry to estimate resting metabolic rate; 3)assess the relationship between energy availability, hormones that regulate bone turnover, markers of bone formation and resorption and bone mineral content and density; 4)identify the relationship between energy availability, hormones that regulate menstrual function and current menstrual status; and 5)determine the energy intake and energy expenditure variables exhibiting the strongest associations with energy availability.

Interventions

None listed

Sponsors

San Diego State University
CollaboratorOTHER
USDA, Western Human Nutrition Research Center
Lead SponsorFED

Study design

Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Age
15 Years to 17 Years
Healthy volunteers
Yes

Inclusion criteria

* high school female cross country runners * ages 15-17 years * 1-5 years experience as cross country runner * 25 miles or more/week training

Exclusion criteria

* medications known to affect bone metabolism * pregnancy

Design outcomes

Primary

MeasureTime frame
Bone density3 months

Secondary

MeasureTime frame
Energy availability3 months

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 31, 2026