Postoperative Analgesia After Laparoscopic Living Donor Nephrectomy

Perioperative Administration of Pregabalin in Laparoscopic Living Donor Nephrectomy (L-LDN) - an Adjuvance to Peroral Analgetic Treatment - a Randomized Controlled Study

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01059331

Enrollment

Registered

2010-01-29

Start date

2010-02-28

Completion date

2012-12-31

Last updated

2014-03-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Living Donors

Keywords

Kidney

Brief summary

The aim of the study is to investigate if perioperative administration of pregabalin vil reduce postoperative pain and the postoperative need for intravenous opioids compared with todays standard treatment which consist of paracetamol, corticoids and ketobemidone. In addition potential sideeffects as sedation and effect on cognitive function will be recorded.

Interventions

DRUGPregabalin

150 mg x 2 daily for 2 days

DRUGSugar pill

1 tablet x 2 daily, for 2 days

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* \>18, \< 75 years * healthy patients accepted for laparoscopic living donor nephrectomy

Exclusion criteria

* not familiar to the Norwegian language (spoken and written) * allergic to one or more of the medication given in the study

Design outcomes

Primary

Measure	Time frame
Opioid consumption in milligrams Pain Score given as Numeric Rating Scale (NRS)	Daily troughout the hospital stay, approx. 6 days

Secondary

Measure	Time frame
Sedation and cognitive function	Daily troughout the hospital stay, approx. 6 days

Countries

Norway

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026