Frozen Embryo Pregnancy Rate
Conditions
Keywords
FET, Progesterone Support, Frozen Embryo Transfer
Brief summary
There have been two very common forms of progesterone administration that have been used during ovulation induction, in vitro fertilization (IVF) and embryo transfers. There are currently no randomized clinical trials to demonstrate which method of progesterone administration is more effective for frozen embryo transfer. We raise the question: Is there a difference between the two accepted methods of progesterone administration, intramuscular and vaginal suppositories, for frozen embryo transfer? Studies for fresh embryo transfer after in vitro fertilization, have demonstrated that there is not a difference between the two methods of progesterone administration. We will evaluate the question for frozen embryo transfer.
Interventions
DRUGProgesterone Vaginal Suppositories
Progesterone Vaginal Suppositories 200 mg three times daily for 10 weeks following embryo transfer
DRUGIntramuscular Progesterone-in-Oil
Progesterone-in-Oil 50 mg IM once daily for 10 weeks following embryo transfer
Sponsors
Charles Coddington
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Females \< 50 years of age * Having frozen embryo transfer at Mayo Clinic * Embryos have been created prior to age 42 * Willing to be randomized to either method of progesterone administration
Exclusion criteria
* Diagnosis of severe medical illness * Uterine lesions affecting the cavity or endometrium * Uterine anomaly * Presence of hydrosalpinx * Extreme difficulty with embryo transfer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical Pregnancy Rate | 3 years |
Secondary
| Measure | Time frame |
|---|---|
| Implantation rate | 3 years |
Countries
United States
Outcome results
None listed