Recurrent Respiratory Papillomatosis
Conditions
Keywords
respiratory, papilloma, pediatric, juvenile
Brief summary
Juvenile onset recurrent respiratory papillomatosis (JORRP) is a rare, difficult to treat, benign tumor of the pediatric airway. Current therapy is mainly surgical, but in a significant portion of patients adjuvant therapy is required to control the disease process. Although multiple adjuvant medical therapies have been tried, success has been limited. We have seen some success in a limited amount of patients using orally administered propranolol. Our goal is to enroll a larger cohort of patients to determine the effectiveness of propranolol as an adjuvant therapy for JORRP.
Interventions
DRUGPropranolol
Propranolol 2mg/kg divided twice daily
Sponsors
Massachusetts Eye and Ear Infirmary
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Years to 10 Years
Healthy volunteers
No
Inclusion criteria
* 1\. Biopsy proven with appropriate Human Papilloma Virus typing Recurrent Respiratory Papilloma * 2\. Child under age 10 * 3\. Informed consent and where appropriate informed assent * 4\. Children who have undergone at least 4 documented surgical interventions in the past year.
Exclusion criteria
* Parental or child refusal to participate * Heart failure * Atrio-ventricular heart block * Cardiac anomalies * Low resting heart rate * Low resting blood pressure * Wolff-Parkinson White Syndrome * Unexplained syncope * Asthma or Reactive airway disease * Renal or liver failure * Expected long fasting periods, \>12 hours * Diabetes Mellitus * Hypersensitivity to propranolol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decreased number of surgeries | 3 months |
Secondary
| Measure | Time frame |
|---|---|
| Improved voice quality | 3 months |
Outcome results
None listed