High-Field MRI Characterization of Wrist and Hand Cartilage Abnormalities in Inflammatory and Chronic Rheumatisms

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01058161

Enrollment

Registered

2010-01-28

Start date

2009-12-31

Completion date

2013-02-28

Last updated

2014-08-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abnormality, Inflammation, Rheumatism

Keywords

wrist and hand cartilage abnormalities in inflammatory and chronic rheumatisms

Brief summary

The present project aims at evaluating the diagnostic potential of high-field MRI (3 Teslas) for joint disease. At this field, given that isotropic image resolution of 400 microns can be obtained, one could expect an early detection of joint abnormalities. The additional aim of this project will be to develop a quantitative analyse of the corresponding high-resolution images.

Interventions

OTHERhigh-field MRI (3 Teslas)

high-field MRI (3 Teslas)

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* gp Suspects or affected by rheumatoid polyarthritis 1. Morning articular Stiffness of at least 15 minutes. 2. Arthalgias or Arthritises of at least three joints(articulations), among which those of the hand. 3. Possible rheumatoid Presence of a factor(mailman) and\\or Antibody anti peptides positive citrullinés. 4. Typical possible radiological Hurts on the standard clichés(pictures) of the reached(affected) joints(articulations). * gp Affected by stiffening spondylitis with axial and peripheral infringement : . Lumbago and steepness lumbar vertebra inflammatory. 2. Arthralgias and\\or peripheral arthritises 3. Possible presence of an allèle HLA 4. Possible presence of a sacro-illite 5. Absence of the other rheumatic markers * gp Affected by connectivity with anti-nuclear antibody positive and / or specific antibodies, suffering of polyarthralgias with or without arthritis * gp Healthy control * gp Presenting a degenerative osteoarthritis of the wrist traumatic comment, noticed radiologically, which will serve as not inflammatory control.

Exclusion criteria

* Claustrophobia, * metallic foreign bodies, * pacemakers The pregnant women, * parturients or who breast-feed are excluded from the study

Design outcomes

Primary

Measure	Time frame
can be obtained, one could expect an early detection of joint abnormalities	24 months

Secondary

Measure	Time frame
will be to develop a quantitative analyse of the corresponding high-resolution images.	24 months

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026