Schizophrenia
Conditions
Keywords
schizophrenia, first episode, atypical antipsychotics, psychosocial intervention, outcome, effectiveness
Brief summary
Schizophrenia is not a curable but a treatable disease by antipsychotics. Kinds of atypical antipsychotics are widely used since 1990s' in China. Although their efficacy for acute phase are all better than typicals, individulized regimen of them for first-episode schizophrenia and their effectiveness in real naturalistic clinical settings still remain unclear. And those patients also need more comprehensive intervention such as psychosocial programs to improve their function. This protocol is to conduct a study in several sites of China to investigate the effectiveness of comprehensive intervention combining sequenced atypical antipsychotic therapy and intensive psychosocial intervention for first-episode schizophrenic patients. In addition, this protocol also aims at collecting such information as molecular genetics, neurochemical test, neucognitive performance and neuroimaging for outcome analysis.
Interventions
DRUGrisperidone
3-6 mg per day
DRUGolanzapine
5-20 mg per day
DRUGAripiprazole
10-30 mg per day
Sponsors
Ministry of Science and Technology of the People´s Republic of China
Peking University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
16 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* schizophrenic patients diagnosed with DSM-IV criteria by SCID-I. * age between 16-45 years old * with disease course less than 3 years and during their first episode * without receiving systematic antipsychotic treatment less than 1 month
Exclusion criteria
* organic disease or unstable physical diseases. * brain trauma with loss of consciousness more than 1 hour * current substance misuse (in 3 months) or any substance dependence. * pregnant women. * patients with severe suicidal imaginations or behavior. * mental retardation * contradict to the study drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the time the patients remain stable | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| Scoring of PANSS and PSP | 1 year |
Countries
China
Contacts
Primary ContactYanbo Yuan, M.D.
Outcome results
None listed