Sarcopenia
Conditions
Keywords
Sarcopenia, Aging, Muscle, Dietary Supplement, HMB, Arginine, Glutamine
Brief summary
The purpose of this study is to determine whether older adults (ages 65-89) who consume the dietary supplement Juven (Abbott Laboratories) versus placebo for 6 months will demonstrate increases in fat-free mass, muscle volume,and physical function.
Interventions
DIETARY_SUPPLEMENTJuven
Participants in the treatment arm will be asked to consume 2 packets of Juven drink mix each day for a period of six months.
Sponsors
National Center for Complementary and Integrative Health (NCCIH)
University of Alabama at Birmingham
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to 89 Years
Healthy volunteers
Yes
Inclusion criteria
* Ages 65-89 * Ambulatory
Exclusion criteria
* Cognitive impairment * History of renal or hepatic disease * History of hypotension * History of peripheral artery disease * Uncontrolled hypertension * Uncontrolled diabetes * Self-reported claustrophobia * Current smoker * Steroid or androgen use with the previous 3 months * Individuals with pacemakers and defibrillators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fat-free mass as determined by a four-compartment model of body composition | Baseline, 3-months, 6-months |
Secondary
| Measure | Time frame |
|---|---|
| Appendicular lean mass as determined by dual energy X-ray absorptiometry | Baseline, 3-months, 6-months |
| Muscle volume as determined by magnetic resonance imaging | Baseline and 6-months |
| Physical function as determined by questionnaire and a battery of physical performance tests | Baseline and 6 months |
Countries
United States
Outcome results
None listed