Healthy
Conditions
Keywords
avenanthramide, enriched, oat, phytochemical, bioavailability
Brief summary
This is a placebo-controlled, crossover study investigating the pharmacokinetic bioavailability of avenanthramides from avenanthramide-enriched oats and their in vivo metabolites in a cohort of healthy, older adults.
Interventions
Single dose, 24 hour pharmacokinetic trial
Sponsors
Agriculture and Agri-Food Canada
Tufts University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
50 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Men and postmenopausal women * BMI 18.5-29.9 kg/m2
Exclusion criteria
* Cigarette smoking and/or nicotine replacement use * Use of cholesterol-lowering medications * Use of blood pressure-lowering medications * Use of any stomach acid-lowering medications * Cardiovascular (heart) disease * Gastrointestinal disease * Kidney disease * Endocrine disease: including diabetes, untreated thyroid disease * Rheumatoid arthritis * Active treatment for any type of cancer, except basal cell carcinoma, within 1 year prior to study admission * Systolic blood pressure \> 150 mm Hg and/or diastolic blood pressure \> 95 mm Hg * Regular use of oral steroids * Regular daily intake of 2 or more alcoholic drinks * Illicit drug use * No fish oil supplements (including cod liver oil) for one month prior to study admission * No dietary supplements, including those containing any vitamins, minerals, herbs, plant concentrates (including garlic, gingko, St. John's wort) or homeopathic remedies, for one month prior to study admission
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of avenanthramides and their in vivo metabolites in blood, urine, and feces following the consumption of avenanthramide-enriched oats delivered in a baked muffin | 24 hours |
Countries
United States
Outcome results
None listed