Optimisation of Cardiac Resynchronisation Therapy by Non-invasive Cardiac Output - The CHOICE2 Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01055210

Acronym

CHOICE2

Enrollment

Registered

2010-01-25

Start date

2010-02-28

Completion date

2013-08-31

Last updated

2018-12-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Resynchronisation Pacemakers, Heart Failure

Keywords

Heart Failure, Pacemakers

Brief summary

An evaluation of the role of resting and exercise cardiac output measurement, by the inert gas rebreathing method, in optimisation of patients with cardiac resynchronisation pacemakers.

Interventions

DEVICEOptimisation of VV delay

Programmed VV delay altered on device

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

* Cardiac Resynchronization Device in situ for Heart Failure

Exclusion criteria

* Unable to cope with mouthpiece * Estimated life expectancy \< 6 months

Design outcomes

Primary

Measure	Time frame
6 minute hall walk test	4 months

Secondary

Measure	Time frame
Echocardiographic measures of desynchrony	3 months

Countries

United Kingdom

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026