Respiratory Distress Syndrome, Ventilation
Conditions
Keywords
Non-invasive ventilation, SiPAP, CPAP, low birth weight infants, respiratory distress syndrome
Brief summary
Investigation of effects of SiPAP versus NCPAP on oxygenation and ventilation in LBW infants with respiratory distress. Our hypothesis is that the LBW infants will achieve the same level of oxygenation and improved ventilation when being treated with SiPAP as compared to NCPAP.
Interventions
DEVICESiPAP
biphasic CPAP (SiPAP) to be alternated in 1 hour blocks with NCPAP
Sponsors
Children's Hospitals and Clinics of Minnesota
Study design
Observational model
CASE_CROSSOVER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
1. LBW infant (birth weight \<2500 grams) 2. Currently on nasal CPAP 3. Use of nasal CPAP for \>24 hours prior to study initiation 4. If history of intubation with mechanical ventilation, patient will be extubated \>24 hours prior to study initiation 5. FiO2 requirement of 25-50%
Exclusion criteria
1. FiO2 requirement \>0.5 2. Congenital defects/deformities of the head, pulmonary or cardiovascular systems 3. Chromosomal abnormalities/genetic syndromes 4. Active medical treatment for symptomatic PDA 5. Active medical treatment for culture proven sepsis 6. Within 24 hours of invasive surgical procedure
Countries
United States
Outcome results
None listed