PET Imaging in Parkinson Disease Dementia

Investigations of Dementia in Parkinson Disease

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01052350

Enrollment

320

Registered

2010-01-20

Start date

2006-08-01

Completion date

2030-07-01

Last updated

2026-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's Disease

Keywords

Parkinson disease, PET imaging, PIB, dementia

Brief summary

Detailed description

The purpose of this study is to use a brain imaging method called PIB PET to determine dementia subtypes in patients with Parkinson's disease. The ultimate goal of this project is to be able to identify individuals with PD who are at risk of developing dementia, and to distinguish the underlying cause of dementia. We will be including both PD and normal subjects in this study. This a long term study and we are considering including a total of 320 participants in this protocol.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* PD patients must exhibit three of the following cardinal signs: rest tremor, rigidity, bradykinesia, or postural instability; or two of these features with one of the first three displaying asymmetry.

Exclusion criteria

* history of head trauma, major neurological or psychiatric diseases other than Parkinson disease and dementia, e.g. stroke, multiple sclerosis, depression or schizophrenia * severe systemic diseases * inability to lie still for 90 minutes * metallic implants, pacemakers, or any other contraindication to MRI * refusal to consent to brain donation

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORJoel S. Perlmutter, MD

Washington University School of Medicine

Outcome results