Esophageal Cancer
Conditions
Keywords
PET Positron emission tomography, CT X-ray computed tomography, Patients with Locally Advanced Esophageal Cancer
Brief summary
The purpose of this study is to evaluate the investigators ability to obtain reliable and meaningful 11C-Choline PET-CT images of esophageal cancer.
Interventions
DRUGC11-Choline
15 mCi 11C-choline will be administered intravenously as a bolus. The whole body emission scans will be acquired immediately following the tracer injection.
Sponsors
Wake Forest University Health Sciences
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Newly diagnosed or recurrent patients with locally advanced esophageal cancer with either squamous or adenocarcinoma histology. * Ability to tolerate PET imaging * Prior malignancy is allowed, but the expectation of survival must be that beyond that expected for patients with locally advanced esophageal cancer.
Exclusion criteria
* Pregnant or lactating females are not eligible for this pilot study. * Patients having received chemotherapy in the 3 months prior to registration for any reason * Patients with metastatic disease requiring chemoradiation for palliation are not allowed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate our ability to obtain reliable and meaningful 11C-Choline PET-CT images of esophageal cancer (pre- and post- chemotherapy). | 2 years |
Secondary
| Measure | Time frame |
|---|---|
| Perform semi-quantitative analysis of tracer uptake using standard uptake values (SUV) and qualitative analysis using pure visual analysis. | 2 years |
Countries
United States
Outcome results
None listed