Chronic Renal Failure
Conditions
Keywords
erythropoietin, hemodialysis, cost utility, incremental cost-effectiveness ratio, Quality adjusted life year, quality of life
Brief summary
To study the cost utility analysis of Erythropoietin (EPO) for maintaining the different hemoglobin (Hb) target levels in anemic hemodialysis patient in routine clinical practice.
Detailed description
In Thailand, the studies that were conducted to find the most useful target Hb have not included the cost effectiveness and/or cost utility analyses. The level at which quality of life is maximized and risk is minimized would be the optimal target. Dialysis patients carry higher risk of death than general population. Anemia is the common complication found in dialysis patients that could lead to mortality. Risk of anemia is occurred in HD patients more than CAPD patients because blood loss is less marked and residual renal function maybe better preserved in patients who receive peritoneal dialysis.Although EPO has been included in the National List of Essential Drugs (NLED) for the treatment of anemia caused by end stage renal disease for maintaining the target hemoglobin but the cost of EPO is so expensive. Cost utility analysis is economic technique for assessing the efficiency of healthcare intervention measuring combined outcomes as the effectiveness, i.e., survival and quality of life in combination as quality adjusted life years (QALYs).This study is a benefit measure at the care giving level by using as a part of planning patient management program and at the policy level for decision making.
Interventions
DRUGerythropoietin
Sponsors
Mahidol University
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Patients use EPO at least 6 months with titration of EPO therapy is permitted
Exclusion criteria
* Patients under 18 years old. * Patients who have blood transfusion for anemic treatment within 6 months before EPO treatment and before the study starts * Patients who change the modality of dialysis * Patients who switch to other anemia treatment method between the study * Patients who cannot answer the questionnaire and are not willing to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The utility scores of hemodialysis (HD) patients who use EPO to maintain the Hb target level. | 1 year |
| Cost of HD patients who use EPO to maintain the Hb target level. | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| The incremental cost-effectiveness ratio (calculated as the ratio between the incremental differences in costs and QALYs associated with 2 alternative treatments) of EPO at the different Hb target levels in HD patients in routine clinical practice. | lifetime horizon (Economic evaluation term) |
Countries
Thailand
Outcome results
None listed