Renin Angiotensin System
Conditions
Keywords
renin-angiotensin system, apelin, systemic haemodynamics
Brief summary
The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease. Apelin improves that pumping ability of the heart and we wish to know if this action persists in the presence of increased levels of angiotensin II.
Interventions
DRUGAngiotensin II
Infusion of a subpressor dose of angiotensin II will be give, this will be 0.5microG/min/kg. Thereafter thre ascending doses of apelin will be given, during which time cardiac output and systemic haemodynamics will be measured.
DRUGSaline
Infusion of saline. Thereafter three ascending doses of apelin will be given, during which time cardiac output and systemic haemodynamics will be measured.
Sponsors
University of Edinburgh
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* \> 18 years old * Healthy volunteers
Exclusion criteria
* Lack of informed consent * Age \< 18 years, * Current involvement in other research studies, * Systolic blood pressure \>190 mmHg or \<100 mmHg * Malignant arrhythmias * Renal or hepatic failure * Haemodynamically significant aortic stenosis * Severe or significant co morbidity * Women of childbearing potential. Any regular medication * Previous history of any cardiovascular disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac output | 90 mins |
Secondary
| Measure | Time frame |
|---|---|
| Systemic haemodynamics | 90mins |
Countries
United Kingdom
Outcome results
None listed